About   Help   FAQ
GpnmbR150X
Spontaneous Allele Detail
Nomenclature
Symbol: GpnmbR150X
Name: glycoprotein (transmembrane) nmb; iris pigment dispersion
MGI ID: MGI:2177814
Synonyms: Gpnmbipd
Gene: Gpnmb  Location: Chr6:49036518-49058182 bp, + strand  Genetic Position: Chr6, 23.82 cM
GpnmbR150X/GpnmbR150X mouse eyes develop a pronounced peripupillary swelling

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  DBA/2J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation details
Inheritance:    Not Specified
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 1 line available
Carrying any Gpnmb Mutation:  7 strains or lines available
Notes

The mouse strain DBA/2J develops glaucoma associated with iris stromal atrophy and iris pigment dispersion phneotypes. Genetic studies defined two separate loci that contribute to the overall phenotype in the DBA/2J mouse, ipd and isa. Either mutation in a homozygous state contributes to glaucoma, while mice homozygous for both mutations develop an earlier onset and more severe iris disease.

References
Original:  J:54013 Chang B, et al., Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice. Nat Genet. 1999 Apr;21(4):405-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory