Ptgs2^tm1Mmt
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm1Mmt
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 1, Makoto M Taketo
• MGI ID: MGI:2177810
• Synonyms: Ptgs2^lacZ
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm1Mmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36816
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene followed by a neomycin selection cassette was fused in frame into exon 2. Western blot analysis confirmed that a beta-galactosidase fusion protein was expressed from this allele. (J:36816)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 72 strains or lines available

References

• Original: J:36816 Oshima M, et al., Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell. 1996 Nov 29;87(5):803-9
• All: 2 reference(s)