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Targeted Allele Detail
Symbol: Evx1tm1Mrc
Name: even skipped homeotic gene 1 homolog; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:2177782
Synonyms: evx1-
Gene: Evx1  Location: Chr6:52313498-52318378 bp, + strand  Genetic Position: Chr6, 25.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:20014
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a DNA segment coding for the first amino acid residues of the first helix of the homeobox domain and part of intron 2. (J:20014)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Evx1 Mutation:  1 strain or line available

These mice have a second closely linked mutation that is thought to underlie the observed early embryonic lethality, and therefore it may not be due to the Evx1 mutation. See the discussion in the following reference: J:70192.

Original:  J:20014 Spyropoulos DD, et al., Targeted disruption of the even-skipped gene, evx1, causes early postimplantation lethality of the mouse conceptus. Genes Dev. 1994 Aug 15;8(16):1949-61
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory