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Il11ra1tm2Gos
Targeted Allele Detail
Nomenclature
Symbol: Il11ra1tm2Gos
Name: interleukin 11 receptor, alpha chain 1; targeted mutation 2, Achim Gossler
MGI ID: MGI:2177775
Synonyms: IL-11RalphaTgH(PGK-neo-rev)
Gene: Il11ra1  Location: Chr4:41699989-41769474 bp, + strand  Genetic Position: Chr4, 21.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48920
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting event resulted a neomycin resistance gene in reverse transcriptional orientation to the gene inserted into intron 8, followed by a truncated, promoterless Il11ra1 gene lacking exons 2-13. Northern blot experiments on RNA derived from kidney of homozygous mice demonstrated that an aberrant transcript was produced from this allele. It was a size consistent with the splicing around the neo cassette to produce a transcript that contains exon 1-8 fused to exons 2-13. Western blot analysis on kidney extracts confirmed that an aberrantly sized protein was expressed from this allele. (J:48920)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il11ra1 Mutation:  17 strains or lines available
References
Original:  J:48920 Bilinski P, et al., Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice. Genes Dev. 1998 Jul 15;12(14):2234-43
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory