Htt^tm1Detl
Targeted Allele Detail

Summary

• Symbol: Htt^tm1Detl
• Name: huntingtin; targeted mutation 1, Peter J Detloff
• MGI ID: MGI:2177756
• Synonyms: CHL1, Hdh^(CAG)80
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm1Detl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67074
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• This allele carries 80 CAG repeat units in the first exon of the endogenous gene. (J:67074)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 179 strains or lines available

References

• Original: J:67074 Lin CH, et al., Neurological abnormalities in a knock-in mouse model of Huntington's disease. Hum Mol Genet. 2001 Jan 15;10(2):137-44
• All: 4 reference(s)