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Gcktm1.2Mgn
Targeted Allele Detail
Nomenclature
Symbol: Gcktm1.2Mgn
Name: glucokinase; targeted mutation 1.2, Mark A Magnuson
MGI ID: MGI:2177710
Synonyms: gkdel
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51826
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Gcktm1Mgn in which all the loxP flanked sequences including exons 9 and 10 as well as the neomycin selection cassette were deleted by injecting heterozygous fertilized eggs with a plasmid expressing Cre recombinase. Progeny were screened for the allele in which all sequences were deleted. (J:51826)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  37 strains or lines available
References
Original:  J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory