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Targeted Allele Detail
Symbol: Gcktm1Tka
Name: glucokinase; targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2177703
Synonyms: GK deficient
Gene: Gck  Location: Chr11:5900820-5950081 bp, - strand  Genetic Position: Chr11, 3.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:30334
Parent Cell Line:  A3-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 1beta, which contains the promoter for the pancreatic-specific isoform of the gene. Glucose phosphorylation assays on samples derived from pancreatic islets and liver tissue of homozygous mice confirmed that no functional protein was expressed in the pancreas, but liver expression was unaffected. (J:30334)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gck Mutation:  26 strains or lines available
Original:  J:30334 Terauchi Y, et al., Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem. 1995 Dec 22;270(51):30253-6
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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