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Targeted Allele Detail
Symbol: Gabra1tm1Twr
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; targeted mutation 1, Thomas W Rosahl
MGI ID: MGI:2177612
Synonyms: alpha1 -, alpha10
Gene: Gabra1  Location: Chr11:42130939-42182930 bp, - strand  Genetic Position: Chr11, 24.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:69290
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 4 and part of intron 4 was replaced with a loxP flanked neomycin resistance cassette. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Western blot analysis on brain lysates derived from homozygotes confirmed that no detectable protein is expressed from this allele. (J:69290)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:  19 strains or lines available
Original:  J:69290 Sur C, et al., Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice. J Neurosci. 2001 May 15;21(10):3409-18
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory