E2f3^tm1.2Gle
Targeted Allele Detail

Summary

• Symbol: E2f3^tm1.2Gle
• Name: E2F transcription factor 3; targeted mutation 1.2, Gustavo Leone
• MGI ID: MGI:2177428
• Synonyms: E2F3-
• Gene: E2f3 Location: Chr13:30090558-30170046 bp, - strand Genetic Position: Chr13, 13.09 cM, cytoband A3.3
• Alliance: E2f3^tm1.2Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75726
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 3 and an additional loxP site was inserted downstream of the exon. Transient expression of Cre recombinase in ES cells excised both the neo cassette and exon 3. (J:75726)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f3 Mutation: 32 strains or lines available

References

• Original: J:75726 Leone G, et al., Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell. 2001 Jul;8(1):105-13
• All: 11 reference(s)