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Brca2tm1Brd
Targeted Allele Detail
Nomenclature
Symbol: Brca2tm1Brd
Name: breast cancer 2, early onset; targeted mutation 1, Allan Bradley
MGI ID: MGI:2177233
Synonyms: Brca2Brdm1, Brca2tmBrd1
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39764
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-hprt minigene cassette replaced 2.8 kb of coding sequences corresponding to amino acids 626-1437 of the encoded protein. (J:39764)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  62 strains or lines available
References
Original:  J:39764 Sharan SK, et al., Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 [see comments]. Nature. 1997 Apr 24;386(6627):804-10
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory