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Brca2tm2Arge
Targeted Allele Detail
Summary
Symbol: Brca2tm2Arge
Name: breast cancer 2, early onset; targeted mutation 2, Argiris Efstratiadis
MGI ID: MGI:2177211
Synonyms: Brca2flox
Gene: Brca2  Location: Chr5:150446095-150493794 bp, + strand  Genetic Position: Chr5, 89.52 cM
Alliance: Brca2tm2Arge page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70564
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site followed by a neomycin selection cassette was inserted 5' to exon 3 and a single loxP site was inserted 3' to exon 4. (J:70564)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Brca2tm2Arge
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  132 strains or lines available
References
Original:  J:70564 Ludwig T, et al., Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene. 2001 Jul 5;20(30):3937-48
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory