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Brca2tm2Arge
Targeted Allele Detail
Nomenclature
Symbol: Brca2tm2Arge
Name: breast cancer 2, early onset; targeted mutation 2, Argiris Efstratiadis
MGI ID: MGI:2177211
Synonyms: Brca2flox
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70564
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site followed by a neomycin selection cassette was inserted 5' to exon 3 and a single loxP site was inserted 3' to exon 4. (J:70564)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  85 strains or lines available
References
Original:  J:70564 Ludwig T, et al., Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene. 2001 Jul 5;20(30):3937-48
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory