About   Help   FAQ
Fxntm2Mkn
Targeted Allele Detail
Nomenclature
Symbol: Fxntm2Mkn
Name: frataxin; targeted mutation 2, Michel Koenig
MGI ID: MGI:2177176
Synonyms: FrdaL3
Gene: Fxn  Location: Chr19:24261453-24280586 bp, - strand  Genetic Position: Chr19, 19.39 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75420
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP-flanked neomycin resistance cassette was inserted 5' to exon 4 and a single loxP site was inserted 3' to exon 4. (J:75420)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fxn Mutation:  30 strains or lines available
References
Original:  J:75420 Puccio H, et al., Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat Genet. 2001 Feb;27(2):181-6
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory