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Cebpatm1Kgx
Targeted Allele Detail
Nomenclature
Symbol: Cebpatm1Kgx
Name: CCAAT/enhancer binding protein (C/EBP), alpha; targeted mutation 1, Kleanthis G Xanthopoulos
MGI ID: MGI:2177068
Synonyms: Cebpa-, C/EBPalpha-
Gene: Cebpa  Location: Chr7:35119293-35121926 bp, + strand  Genetic Position: Chr7, 21.02 cM
Abnormal liver and lung morphology in Cebpatm1Kgx/Cebpatm1Kgx mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:35795
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted downstream of both translation initiation codons, resulting in stop codons in all three reading frames. Northern blot analysis on RNA derived from liver of homozygous mice demonstrated that a large fusion transcript was made that incorporated both the gene and the neomycin cassette elements. However, western blot experiments on liver lysates from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:35795)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cebpa Mutation:  3 strains or lines available
References
Original:  J:35795 Flodby P, et al., Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. J Biol Chem. 1996 Oct 4;271(40):24753-60
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory