Mei1^m1Jcs
Chemically induced Allele Detail

Summary

• Symbol: Mei1^m1Jcs
• Name: meiotic double-stranded break formation protein 1; mutation 1, John C Schimenti
• MGI ID: MGI:2176973
• Synonyms: mei1, meiosis defective 1
• Gene: Mei1 Location: Chr15:81954275-82011018 bp, + strand Genetic Position: Chr15, 38.41 cM, cytoband E2
• Alliance: Mei1^m1Jcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60747
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in an EMS mutagenesis screen for infertile mice. The molecular defect is an A-to-T transversion at the AG splice acceptor sequence of intron 11. Two aberrantly spliced transcripts are expressed from this allele, both resulting in a frameshift of the wild-type sequence and a premature stop codon.
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mei1 Mutation: 56 strains or lines available

References

• Original: J:60747 Munroe RJ, et al., Mouse mutants from chemically mutagenized embryonic stem cells. Nat Genet. 2000 Mar;24(3):318-21
• All: 10 reference(s)