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Bdnftm3Jae
Targeted Allele Detail
Nomenclature
Symbol: Bdnftm3Jae
Name: brain derived neurotrophic factor; targeted mutation 3, Rudolf Jaenisch
MGI ID: MGI:2176750
Synonyms: Bdnf2, Bdnf2L, Bdnf2lox, Bdnflox, Bdnftm2Jae
Gene: Bdnf  Location: Chr2:109674700-109727007 bp, + strand  Genetic Position: Chr2, 56.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71969
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was inserted 5' to the only coding exon, and a loxP-flanked hygromycin resistance cassette was inserted 3' to the exon. The hygromycin selection cassette was removed in ES cells by transient Cre expression leaving a single loxP site prior to the production of chimeric mice. (J:71969)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:  21 strains or lines available
References
Original:  J:71969 Rios M, et al., Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol. 2001 Oct;15(10):1748-57
All:  60 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory