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Targeted Allele Detail
Symbol: Bcl2l1tm1.1Mam
Name: BCL2-like 1; targeted mutation 1.1, Lothar Hennighausen
MGI ID: MGI:2176700
Synonyms: Bcl-xf, fl
Gene: Bcl2l1  Location: Chr2:152780668-152831728 bp, - strand  Genetic Position: Chr2, 75.41 cM, cytoband H1
Germline Transmission:  Earliest citation of germline transmission: J:63161
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThis allele is a derivative of Bcl2ltm1Mam in which the loxP flanked neomycin cassette was removed in the germline by mating mice carrying this allele to Tg(EIIa-Cre)1Lmgd mice. A single loxP site remains in place of the loxP flanked selection cassette and a second loxP site is located 3' to exon 2 in the final allele. (J:63161)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcl2l1 Mutation:  119 strains or lines available
Original:  J:63161 Rucker EB 3rd, et al., Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol Endocrinol. 2000 Jul;14(7):1038-52
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory