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Targeted Allele Detail
Symbol: Fhittm1Hbn
Name: fragile histidine triad gene; targeted mutation 1, Kay Huebner
MGI ID: MGI:2176611
Synonyms: Fhit-, Fhittm2KCC
Gene: Fhit  Location: Chr14:9550092-11162035 bp, - strand  Genetic Position: Chr14, 5.61 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:61946
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA termination codon, a GFP gene and a loxP flanked neomycin selection cassette were inserted into exon 5. Immunoblot analysis showed that homozygous mouse tissues were entirely negative for the encoded protein, and immunohistochemical detection in kidney sections of homozygous mice showed absence of the protein. (J:61946)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fhit Mutation:  3 strains or lines available
Original:  J:61946 Fong LY, et al., Muir-torre-like syndrome in fhit-deficient mice. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4742-7
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory