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Targeted Allele Detail
Symbol: Admtm1Unc
Name: adrenomedullin; targeted mutation 1, University of North Carolina
MGI ID: MGI:2176598
Synonyms: AM-
Gene: Adm  Location: Chr7:110627661-110629820 bp, + strand  Genetic Position: Chr7, 57.7 cM
Massive generalized edema of Admtm1Unc/Admtm1Unc embryos

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67044
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn in-frame EGFP gene and a neomycin resistance cassette were inserted into exon 2, and a genomic fragment corresponding to exons 3 and 4 was deleted. RT-PCR analysis on embryonic RNA of homozygotes demonstrated that no detectable Adm transcript was expressed from this allele. (J:67044)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adm Mutation:  9 strains or lines available
Original:  J:67044 Caron KM, et al., Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):615-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory