Adcy8^tm1Ljm
Targeted Allele Detail

Summary

• Symbol: Adcy8^tm1Ljm
• Name: adenylate cyclase 8; targeted mutation 1, Louis J Muglia
• MGI ID: MGI:2176596
• Synonyms: AC8-, AC8 KO
• Gene: Adcy8 Location: Chr15:64570884-64794145 bp, - strand Genetic Position: Chr15, 29.03 cM
• Alliance: Adcy8^tm1Ljm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63173
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette replaced a genomic fragment containing exon 1, including the translation initiation site. RT-PCR analysis on RNA derived from hypothalamus or hippocampus of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:63173)

Expression

In Mice Carrying this Mutation:	12 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adcy8 Mutation: 80 strains or lines available

References

• Original: J:63173 Schaefer ML, et al., Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice. J Neurosci. 2000 Jul 1;20(13):4809-20
• All: 41 reference(s)