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Targeted Allele Detail
Symbol: Adcy8tm1Ljm
Name: adenylate cyclase 8; targeted mutation 1, Louis J Muglia
MGI ID: MGI:2176596
Synonyms: AC8-, AC8 KO
Gene: Adcy8  Location: Chr15:64699035-64922296 bp, - strand  Genetic Position: Chr15, 29.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:63173
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced a genomic fragment containing exon 1, including the translation initiation site. RT-PCR analysis on RNA derived from hypothalamus or hippocampus of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:63173)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcy8 Mutation:  1 strain or line available
Original:  J:63173 Schaefer ML, et al., Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice. J Neurosci. 2000 Jul 1;20(13):4809-20
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory