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Targeted Allele Detail
Symbol: Ptpn11tm1Paw
Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Anthony Pawson
MGI ID: MGI:2176524
Synonyms: Shp-2 -, Shp2 -, Shp-2delta46-110
Gene: Ptpn11  Location: Chr5:121130533-121191397 bp, - strand  Genetic Position: Chr5, 61.72 cM, cytoband F
Defects in the skin, lung and intestine of Egfrwa2/Egfrwa2 Ptpn11tm1Paw/+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:43740
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 3, which contains sequences encoding the SH2-N motif. RT-PCR analysis on total RNA derived from heterozygous mice demonstrated that a transcript was made from this allele that spliced exon 2 to exon 4, resulting in a message that retained the proper reading frame. Western blot analysis on heterozygous specimins confirmed that a mutant protein is expressed from this allele that is consistent with the size expected. (J:43740)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptpn11 Mutation:  23 strains or lines available
Original:  J:43740 Saxton TM, et al., Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. EMBO J. 1997 May 1;16(9):2352-64
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
The Jackson Laboratory