About   Help   FAQ
Grik1tm1Sfh
Targeted Allele Detail
Nomenclature
Symbol: Grik1tm1Sfh
Name: glutamate receptor, ionotropic, kainate 1; targeted mutation 1, Stephen F Heinemann
MGI ID: MGI:2176347
Synonyms: GLUK5-, GluR5-, GluR5 KO
Gene: Grik1  Location: Chr16:87895900-88290265 bp, - strand  Genetic Position: Chr16, 50.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66021
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 345 bp genomic fragment that contains sequences encoding the membrane I domain required for protein function. Physiological assays on dorsal root ganglion cells of homozygous mice confirmed that no functional receptor was made from this allele. (J:66021)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik1 Mutation:  3 strains or lines available
References
Original:  J:66021 Mulle C, et al., Subunit composition of kainate receptors in hippocampal interneurons. Neuron. 2000 Nov;28(2):475-84
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/06/2019
MGI 6.14
The Jackson Laboratory