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Targeted Allele Detail
Symbol: Grik1tm1Sfh
Name: glutamate receptor, ionotropic, kainate 1; targeted mutation 1, Stephen F Heinemann
MGI ID: MGI:2176347
Synonyms: GLUK5-, GluR5-, GluR5 KO
Gene: Grik1  Location: Chr16:87895900-88290265 bp, - strand  Genetic Position: Chr16, 50.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:66021
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 345 bp genomic fragment that contains sequences encoding the membrane I domain required for protein function. Physiological assays on dorsal root ganglion cells of homozygous mice confirmed that no functional receptor was made from this allele. (J:66021)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Grik1 Mutation:  3 strains or lines available
Original:  J:66021 Mulle C, et al., Subunit composition of kainate receptors in hippocampal interneurons. Neuron. 2000 Nov;28(2):475-84
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory