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Targeted Allele Detail
Symbol: Pou4f2tm1Nat
Name: POU domain, class 4, transcription factor 2; targeted mutation 1, Jeremy Nathans
MGI ID: MGI:2176272
Synonyms: Brn-3b -
Gene: Pou4f2  Location: Chr8:78433010-78436645 bp, - strand  Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
Germline Transmission:  Earliest citation of germline transmission: J:32903
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 4.4 kb genomic fragment containing the entire coding sequence of the gene. (J:32903)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou4f2 Mutation:  4 strains or lines available
Original:  J:32903 Gan L, et al., POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3920-5
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.12
The Jackson Laboratory