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Lag3tm1Doi
Targeted Allele Detail
Nomenclature
Symbol: Lag3tm1Doi
Name: lymphocyte-activation gene 3; targeted mutation 1, Christophe Benoist and Diane Mathis
MGI ID: MGI:2176269
Synonyms: LAG-3-, Lag3tm1Dim
Gene: Lag3  Location: Chr6:124904361-124911705 bp, - strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:32509
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced a genomic fragment containing exons 1-3. RT-PCR analysis on RNA derived from concanavalin A (Con A) induced splenocytes confirmed that no detectable transcript was produced from this allele. (J:32509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lag3 Mutation:  34 strains or lines available
References
Original:  J:32509 Miyazaki T, et al., Independent modes of natural killing distinguished in mice lacking Lag3. Science. 1996 Apr 19;272(5260):405-8
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory