Lag3^tm1Doi
Targeted Allele Detail

Summary

• Symbol: Lag3^tm1Doi
• Name: lymphocyte-activation gene 3; targeted mutation 1, Christophe Benoist and Diane Mathis
• MGI ID: MGI:2176269
• Synonyms: LAG-3^-, Lag3^tm1Dim
• Gene: Lag3 Location: Chr6:124881324-124888668 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Lag3^tm1Doi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:32509
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a genomic fragment containing exons 1-3. RT-PCR analysis on RNA derived from concanavalin A (Con A) induced splenocytes confirmed that no detectable transcript was produced from this allele. (J:32509)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lag3 Mutation: 41 strains or lines available

References

• Original: J:32509 Miyazaki T, et al., Independent modes of natural killing distinguished in mice lacking Lag3. Science. 1996 Apr 19;272(5260):405-8
• All: 29 reference(s)