Il4^tm1Kopf
Targeted Allele Detail

Summary

• Symbol: Il4^tm1Kopf
• Name: interleukin 4; targeted mutation 1, Manfred Kopf
• MGI ID: MGI:2176268
• Synonyms: IL-4-, IL-4^null
• Gene: Il4 Location: Chr11:53503287-53509492 bp, - strand Genetic Position: Chr11, 31.97 cM
• Alliance: Il4^tm1Kopf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:14593
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into the third exon of the gene. (J:14593)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Il4 Mutation: 42 strains or lines available

References

• Original: J:14593 Kopf M, et al., Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature. 1993 Mar 18;362(6417):245-8
• All: 63 reference(s)