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Calrtm1Mlk
Targeted Allele Detail
Nomenclature
Symbol: Calrtm1Mlk
Name: calreticulin; targeted mutation 1, Marek Michalak
MGI ID: MGI:2176266
Synonyms: crt-
Gene: Calr  Location: Chr8:84842088-84846931 bp, - strand  Genetic Position: Chr8, 41.21 cM
Umbilical hernia in Calrtm1Mlk/Calrtm1Mlk mice

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53466
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing the first four coding exons. Western blot analysis on extracts derived from homozygous embryos confirmed that no detectable protein was expressed from this allele. (J:53466)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Calr Mutation:  11 strains or lines available
References
Original:  J:53466 Mesaeli N, et al., Calreticulin is essential for cardiac development. J Cell Biol. 1999 Mar 8;144(5):857-68
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory