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Targeted Allele Detail
Symbol: Smotm1Amc
Name: smoothened, frizzled class receptor; targeted mutation 1, Andrew P McMahon
MGI ID: MGI:2176255
Synonyms: Smo-, Smon, Smonull, Smorec
Gene: Smo  Location: Chr6:29735503-29761365 bp, + strand  Genetic Position: Chr6, 12.36 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:175111
Parent Cell Line:  AV3 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn frt-flanked neomycin resistance cassette replaced a segment containing 44 bp upstream and 358 bp downstream of the translation initiation codon. (J:175111)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 66 assay results
In Structures Affected by this Mutation: 55 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smo Mutation:  9 strains or lines available
Original:  J:175111 Zhang XM, et al., Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node. Cell. 2001 Jul 27;106(2):781-92
All:  61 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory