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Targeted Allele Detail
Symbol: Zap70tm1Weis
Name: zeta-chain (TCR) associated protein kinase; targeted mutation 1, Arthur Weiss
MGI ID: MGI:2176252
Synonyms: ZAP-70 -
Gene: Zap70  Location: Chr1:36761798-36782818 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Germline Transmission:  Earliest citation of germline transmission: J:74974
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing sequences corresponding to amino acids 221 to 520, which encode the C-terminal SH2 domain. Western blot analysis on thymocytes derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:74974)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:  16 strains or lines available
Original:  J:74974 Kadlecek TA, et al., Differential requirements for ZAP-70 in TCR signaling and T cell development. J Immunol. 1998 Nov 1;161(9):4688-94
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory