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Targeted Allele Detail
Symbol: Mapk8tm1Flv
Name: mitogen-activated protein kinase 8; targeted mutation 1, Richard Flavell
MGI ID: MGI:2176239
Synonyms: Jnk1 -, Jnk1 KO
Gene: Mapk8  Location: Chr14:33377898-33447158 bp, - strand  Genetic Position: Chr14, 20.22 cM, cytoband B
Abnormal epidermis of adult Mapk8tm1Flv/Mapk8tm1Flv and Mapk9tm1Flv/Mapk9tm1Flv mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:51510
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA hygromycin resistance cassette replaced a 5.5 kb genomic fragment containing four exons of the gene. Western blot analysis on extracts derived from embryonic fibroblasts of homozygous mice confirmed that no detectable protein was expressed from this allele. (J:51510)
View phenotypes for all genotypes (concatenated display).
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk8 Mutation:  60 strains or lines available
Original:  J:51510 Dong C, et al., Defective T cell differentiation in the absence of Jnk1. Science. 1998 Dec 11;282(5396):2092-5
All:  99 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory