Tg(CMV-cre)1Cgn
Transgene Detail

Summary

• Symbol: Tg(CMV-cre)1Cgn
• Name: transgene insertion 1, University of Cologne
• MGI ID: MGI:2176180
• Synonyms: CMV-Cre, CMV:Cre, Cre deleter, DCre, deleter, TgH(Deleter+8)KP, TgN(CMV-Cre)#Cgn, ubi-cre
• Transgene: Tg(CMV-cre)1Cgn Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Tg(CMV-cre)1Cgn page

Transgene origin

• Strain of Origin: BALB/cJ

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(CMV-cre)1Cgn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  virus	CMV

• Mutation details: This transgene expresses Cre recombinase under the control of a human cytomegalovirus (CMV) promoter, active in most cells and tissues. (J:75204)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CMV (virus) Summary of all recombinase alleles driven by CMV.

Disease models

Expression

In Mice Carrying this Mutation:

125 assay results 7 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CMV-cre)1Cgn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice are viable and fertile. The transgene appears to be X-linked since transgene transmission through males is restricted to female offspring.

In transgenic mice, in conjunction with a transgene carrying a loxP-flanked gene, deletion of the loxP-flanked gene occurs in all tissues including germ cells.

References

• Original: J:75204 Schwenk F, et al., A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 1995 Dec 25;23(24):5080-1
• All: 1086 reference(s)