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Ucp2tm1Lowl
Targeted Allele Detail
Nomenclature
Symbol: Ucp2tm1Lowl
Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 1, Bradford B Lowell
MGI ID: MGI:2176058
Synonyms: Ucp2-
Gene: Ucp2  Location: Chr7:100142544-100148836 bp, + strand  Genetic Position: Chr7, 54.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75196
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced introns 2-7 including the start codon. Northern blot analysis using a full length rat cDNA probe did not detect intact mRNA in any tissues from homozygous mutant mice. Western blot analysis did not detect protein in spleen mitochondria from homozygous mutant mice. (J:75196)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ucp2 Mutation:  36 strains or lines available
References
Original:  J:75196 Zhang CY, et al., Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15;105(6):745-55
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory