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Nf1tm1Par
Targeted Allele Detail
Nomenclature
Symbol: Nf1tm1Par
Name: neurofibromin 1; targeted mutation 1, Luis F Parada
MGI ID: MGI:2176057
Synonyms: Nf1flox, Nf1flox
Gene: Nf1  Location: Chr11:79339693-79581612 bp, + strand  Genetic Position: Chr11, 46.74 cM, cytoband B4-5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68558
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP-neomycin selection cassette was inserted into intron 30 and a single loxP site was inserted into intron 32. (J:68558)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 32 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Nf1 Mutation:  96 strains or lines available
References
Original:  J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
All:  117 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory