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Tg(Syn1-cre)671Jxm
Transgene Detail
Summary
Symbol: Tg(Syn1-cre)671Jxm
Name: transgene insertion 671, Jamey Marth
MGI ID: MGI:2176055
Synonyms: cresyn1, Syn-cre, Syn-Cretg, SynI-Cre
Transgene: Tg(Syn1-cre)671Jxm  Location: unknown  Genetic Position: Chr6, Syntenic
Alliance: Tg(Syn1-cre)671Jxm page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutations:    Duplication, Insertion
 
Tg(Syn1-cre)671Jxm expression driven by 1 gene
 
Mutation detailsThis transgene expresses Cre recombinase under the control of a rat synapsin I promoter. Cre recombinase activity is detected in neuronal cells, including brain, spinal cord and DRGs, as early as E12.5, as well as in neurons in adult. Line 671 contains 10 copies of the transgene inserted into chromosome 6 over 1 Mb from the nearest gene (chr6:10,423,318; NCBI37/mm9) with a duplication of unknown size at the insertion site. (J:68558)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Syn1 (rat)
Summary of all recombinase alleles driven by Syn1.
User Notes:
 Additional information submitted by the research community
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
1 RNA-Seq or microarray experiment(s)
Tumor Data
List all tumor models in MMHCdb carrying Tg(Syn1-cre)671Jxm
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
References
Original:  J:68558 Zhu Y, et al., Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev. 2001 Apr 1;15(7):859-76
All:  203 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory