About   Help   FAQ
Targeted Allele Detail
Symbol: Ucp2tm1Rcq
Name: uncoupling protein 2 (mitochondrial, proton carrier); targeted mutation 1, Daniel Ricquier
MGI ID: MGI:2176053
Synonyms: Ucp2-
Gene: Ucp2  Location: Chr7:100493337-100502020 bp, + strand  Genetic Position: Chr7, 54.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:66262
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsInsertion of a PGK-neomycin resistance cassette deleted 119 bp of exon III downstream of the initiation codon, intron 3, and 68 bp of exon IV, and inserted a stop codon immediately downstream of the aa 13 codon. The deleted sequences encode amino acids 14-73. Western and Northern blot analyses did not detect expression in any tissues from homozygous mutant mice. (J:66262)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucp2 Mutation:  33 strains or lines available
Original:  J:66262 Arsenijevic D, et al., Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000 Dec;26(4):435-9
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory