Tmem163^{Tg(ACTB-cre)2Mrt}
Transgenic Allele Detail

Summary

• Symbol: Tmem163^{Tg(ACTB-cre)2Mrt}
• Name: transmembrane protein 163; transgene insertion 2, Gail R Martin
• MGI ID: MGI:2176050
• Synonyms: A-cre, ACTB-cre, Act-Cre, actin-cre, beta-actin-cre, beta-actin-Cre, beta-actin:Cre, beta-actin::Cre, cre^actin, Tg(ACTB-cre)2Mrt, TgN(ACTB-cre)2Mrt
• Gene: Tmem163 Location: Chr1:127418079-127605758 bp, - strand Genetic Position: Chr1, 55.77 cM, cytoband E3
• Alliance: Tmem163^{Tg(ACTB-cre)2Mrt} page

Reduced body size in Raph1^tm1.1Makr/Raph1^tm1.1Makr Tmem163^{Tg(ACTB-cre)2Mrt}/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Tmem163^{Tg(ACTB-cre)2Mrt} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  ACTB (60)

  Actb	(MGI:87904)

• Mutation details: This transgene expresses Cre recombinase under the control of a human beta-actin promoter, which is active in all embryonic cells at or before the blastocyst stage. Line number 2 contains a single copy of the transgene inserted into intron 4 of Tmem163 (chr1:129,442,346; NCBI37/mm9) with three intronic deletions of 2.2, 7.3 and 3.2 kb, respectively, surrounding the transgene integration site. (J:46833, J:240920)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	ACTB (human) Summary of all recombinase alleles driven by ACTB. Comparative matrix view of recombinase activities Alliance human ACTB gene page

Disease models

Expression

In Mice Carrying this Mutation:

90 assay results

Tumor Data

List all tumor models in MMHCdb carrying Tmem163^{Tg(ACTB-cre)2Mrt}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Tmem163 Mutation: 35 strains or lines available

References

• Original: J:46833 Lewandoski M, et al., Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb Symp Quant Biol. 1997;62:159-68
• All: 380 reference(s)