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Irf2tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Irf2tm1Mak
Name: interferon regulatory factor 2; targeted mutation 1, Tak Mak
MGI ID: MGI:2175949
Synonyms: IRF-2-
Gene: Irf2  Location: Chr8:46739745-46847458 bp, + strand  Genetic Position: Chr8, 26.42 cM, cytoband B2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64286
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the third exon of the gene, which encodes amino acids 30 - 63, part of the DNA-binding domain of the protein. (J:64286)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf2 Mutation:  6 strains or lines available
References
Original:  J:64286 Matsuyama T, et al., Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development. Cell. 1993 Oct 8;75(1):83-97
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory