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Targeted Allele Detail
Symbol: Ccl2tm1Rol
Name: chemokine (C-C motif) ligand 2; targeted mutation 1, Barrett J Rollins
MGI ID: MGI:2175911
Synonyms: CCL2-, CCL2KO, (MCP)1-, MCP-1-, MCP-1KO, Scya2-
Gene: Ccl2  Location: Chr11:82035571-82037453 bp, + strand  Genetic Position: Chr11, 49.82 cM, cytoband C-E1
Ccl2tm1Rol/Ccl2tm1Rol mice with experimental autoimmune encephalomyelitis show fewer inflammatory infiltrates in the spinal cord

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:45920
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA small deletion and an in frame stop codon were created in exon 1. A PGK-neomycin resistance cassette was also inserted into exon 2. Secreted protein was not detected in stimulated peritoneal macrophages from homozygous mutant mice. (J:45920)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl2 Mutation:  9 strains or lines available
Phenotypic Similarity to Human Syndrome: Macular Degeneration, Age-Related (J:126935, J:147328, J:214499).

Phenotypic Similarity to Human Syndrome: Macular Degeneration, Geographic Atrophy, Dry Type (J:200877).

Original:  J:45920 Lu B, et al., Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med. 1998 Feb 16;187(4):601-8
All:  173 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory