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Pik3r2tm1Lca
Targeted Allele Detail
Nomenclature
Symbol: Pik3r2tm1Lca
Name: phosphoinositide-3-kinase regulatory subunit 2; targeted mutation 1, Lewis C Cantley
MGI ID: MGI:2159732
Synonyms: p85beta-, Pik3r2-
Gene: Pik3r2  Location: Chr8:70768176-70776712 bp, - strand  Genetic Position: Chr8, 34.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73703
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting construct was designed to replace the 5' UTR, start codon and first exon with a PGK-neo cassette. (J:97576)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3r2 Mutation:  22 strains or lines available
References
Original:  J:73703 Ueki K, et al., Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):419-24
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory