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Targeted Allele Detail
Symbol: Ocrltm2Nbm
Name: OCRL, inositol polyphosphate-5-phosphatase; targeted mutation 2, Robert L Nussbaum
MGI ID: MGI:2159678
Synonyms: Ocrl1-, Ocrl1polyA-
Gene: Ocrl  Location: ChrX:47912387-47965868 bp, + strand  Genetic Position: ChrX, 25.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:47884
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA truncated PGK-neomycin resistance cassette lacking its polyadenylation sequence replaced exon 20 and half of exons 19 and 21, and placed an in frame stop codon into exon 19. Western blot analysis did not detect protein in any organs from hemizygous mutant male mice. (J:47884)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ocrl Mutation:  6 strains or lines available
Original:  J:47884 Janne PA, et al., Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice. J Clin Invest. 1998 May 15;101(10):2042-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory