Aaq1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Aaq1^C57BL/6J
• Name: alcohol acceptance QTL 1; C57BL/6J
• MGI ID: MGI:2159395
• QTL: Aaq1 Location: unknown Genetic Position: Chr15, cM position of peak correlated region/allele: 16.82 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased alcohol acceptance compared to DBA/2J. (J:43654)
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:52089

A QTL affecting alcohol acceptance, Aaq1, was verified in a (C57BL/6J x DBA/2J)F4 population and in a population of genotypically selected animals. Aaq1 maps to mouse chromosome 15 near D15Mit60 at approximately 25 cM.

J:43654

In the present study Aaq1, a QTL linked to alcohol acceptance that was previously mapped to a candidate region on mouse Chromosome 15 using BXD RI strains, was confirmed using a (C57BL/6J x DBA/2J)F2 population. Aaq1 mapped to 15 cM - 48 cM on mouse Chromosome 15 with a peak LOD score of 3.8 at approximately 30 cM. C57BL/6J-derived alleles confer increased alcohol acceptance in a dominant fashion at Aaq1. A potential candidate gene for Aaq1 is the peripheral benzodiazepine receptor gene, Bzrp.

References

• Original: J:43654 McClearn GE, et al., Genotypic selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse. Mol Psychiatry. 1997 Oct-Nov;2(6):486-9
• All: 1 reference(s)