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Casp12tm1Yuan
Targeted Allele Detail
Nomenclature
Symbol: Casp12tm1Yuan
Name: caspase 12; targeted mutation 1, Junying Yuan
MGI ID: MGI:2159367
Gene: Casp12  Location: Chr9:5345430-5373032 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:59337
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced a segment of intron 3 and exon 4. RT-PCR and western blotting experiments confirmed that no transcript or protein was expressed from this allele (data not shown). (J:59337)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp12 Mutation:  17 strains or lines available
References
Original:  J:59337 Nakagawa T, et al., Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 6;403(6765):98-103
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory