About   Help   FAQ
Casp4tm1Yuan
Targeted Allele Detail
Nomenclature
Symbol: Casp4tm1Yuan
Name: caspase 4, apoptosis-related cysteine peptidase; targeted mutation 1, Junying Yuan
MGI ID: MGI:2159366
Synonyms: casp-11, Casp11-, Caspase-11-
Gene: Casp4  Location: Chr9:5308828-5336783 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46167
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.5 kb genomic fragment containing sequences encoding 16 amino acids of the active site. Western blot analysis on lysates derived from spleen of both LPS-injected and control homozygous mice confirmed that no detectable protein is expressed from this allele. (J:46167)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp4 Mutation:  17 strains or lines available
References
Original:  J:46167 Wang S, et al., Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 1998 Feb 20;92(4):501-9
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/14/2017
MGI 6.11
The Jackson Laboratory