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Targeted Allele Detail
Symbol: Casp4tm1Yuan
Name: caspase 4, apoptosis-related cysteine peptidase; targeted mutation 1, Junying Yuan
MGI ID: MGI:2159366
Synonyms: casp-11, Casp11-, Caspase-11-
Gene: Casp4  Location: Chr9:5308828-5336783 bp, + strand  Genetic Position: Chr9, 2.46 cM, cytoband A1
Germline Transmission:  Earliest citation of germline transmission: J:46167
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a 1.5 kb genomic fragment containing sequences encoding 16 amino acids of the active site. Western blot analysis on lysates derived from spleen of both LPS-injected and control homozygous mice confirmed that no detectable protein is expressed from this allele. (J:46167)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Casp4 Mutation:  25 strains or lines available
Original:  J:46167 Wang S, et al., Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 1998 Feb 20;92(4):501-9
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory