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Faddtm1Wnt
Targeted Allele Detail
Nomenclature
Symbol: Faddtm1Wnt
Name: Fas (TNFRSF6)-associated via death domain; targeted mutation 1, Astar Winoto
MGI ID: MGI:2159365
Gene: Fadd  Location: Chr7:144577318-144582463 bp, - strand  Genetic Position: Chr7, 88.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46526
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing the first exon of the gene was replaced with a neomycin selection cassette. Western blot analysis on homozygous ES cell lines confirmed that no detectable protein is expressed from this allele. (J:46526)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fadd Mutation:  6 strains or lines available
References
Original:  J:46526 Zhang J, et al., Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature. 1998 Mar 19;392(6673):296-300
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/28/2017
MGI 6.11
The Jackson Laboratory