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Targeted Allele Detail
Symbol: Bak1tm1Thsn
Name: BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson
MGI ID: MGI:2159364
Synonyms: bak-
Gene: Bak1  Location: Chr17:27019812-27028627 bp, - strand  Genetic Position: Chr17, 13.65 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:66872
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 2-6. These exons encode the Bcl-2 homology domains of the encoded protein. Western blot analysis on spleen and thymus lysates derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:66872)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 28 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bak1 Mutation:  17 strains or lines available
Original:  J:66872 Lindsten T, et al., The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000 Dec;6(6):1389-99
All:  134 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory