About   Help   FAQ
Bak1tm1Thsn
Targeted Allele Detail
Nomenclature
Symbol: Bak1tm1Thsn
Name: BCL2-antagonist/killer 1; targeted mutation 1, Craig B Thompson
MGI ID: MGI:2159364
Synonyms: bak-
Gene: Bak1  Location: Chr17:27019810-27029009 bp, - strand  Genetic Position: Chr17, 13.65 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66872
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 2-6. These exons encode the Bcl-2 homology domains of the encoded protein. Western blot analysis on spleen and thymus lysates derived from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:66872)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bak1 Mutation:  16 strains or lines available
References
Original:  J:66872 Lindsten T, et al., The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000 Dec;6(6):1389-99
All:  112 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/05/2017
MGI 6.11
The Jackson Laboratory