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Targeted Allele Detail
Symbol: Gpc3tm1Fil
Name: glypican 3; targeted mutation 1, Jorge Filmus
MGI ID: MGI:2159356
Synonyms: Gpc3 -
Gene: Gpc3  Location: ChrX:52272426-52613950 bp, - strand  Genetic Position: ChrX, 28.74 cM, cytoband A3.3
Some Gpc3tm1Fil/Y embryos exhibit mandibular hypoplasia

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:73877
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing part of the promoter and exon 1. Northern blot analysis on RNA derived from E18.5 embryos confirmed that no detectable transcript was produced from this allele. (J:73877)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpc3 Mutation:  16 strains or lines available
Original:  J:73877 Cano-Gauci DF, et al., Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol. 1999 Jul 12;146(1):255-64
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory