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Targeted Allele Detail
Symbol: Nr0b1tm1.1Lja
Name: nuclear receptor subfamily 0, group B, member 1; targeted mutation 1.1, J Larry Jameson
MGI ID: MGI:2159321
Synonyms: Ahchdelta2, Dax1-, Dax1KO
Gene: Nr0b1  Location: ChrX:86191764-86195947 bp, + strand  Genetic Position: ChrX, 39.67 cM
Germline Transmission:  Earliest citation of germline transmission: J:51292
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Nr0b1tm1Lja in which Cre-mediated recombination in vivo under control of a CMV promoter excised exon 2 in the germline. RT-PCR analyses of pituitary, adrenal glands, and gonads did not detect full length transcript in either homozygous female mice or hemizygous male mice. (J:51292)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nr0b1 Mutation:  6 strains or lines available
Original:  J:51292 Yu RN, et al., Role of Ahch in gonadal development and gametogenesis [see comments]. Nat Genet. 1998 Dec;20(4):353-7
All:  16 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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