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Targeted Allele Detail
Symbol: Neurog3tm1Fgu
Name: neurogenin 3; targeted mutation 1, Francois Guillemot
MGI ID: MGI:2159017
Synonyms: ngn3 -, Ngn3neo
Gene: Neurog3  Location: Chr10:61968869-61970542 bp, + strand  Genetic Position: Chr10, 32.35 cM, cytoband B4
Alliance: Neurog3tm1Fgu page
Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 and Neurog3tm3.1Ggr/Neurog3tm3.1Ggr Tg(Vil1-cre)20Syr/0 mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:60642
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 628 bp DNA segment containing 468 bp of coding sequence, including sequences corresponding to the bHLH domain.
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurog3 Mutation:  16 strains or lines available
Original:  J:60642 Gradwohl G, et al., neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1607-11
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory