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Neurog3tm1Fgu
Targeted Allele Detail
Nomenclature
Symbol: Neurog3tm1Fgu
Name: neurogenin 3; targeted mutation 1, Francois Guillemot
MGI ID: MGI:2159017
Synonyms: ngn3 -, Ngn3neo
Gene: Neurog3  Location: Chr10:62133090-62134763 bp, + strand  Genetic Position: Chr10, 32.35 cM, cytoband B4
Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3Ggr Tg(Vil-cre)20Syr/0 and Neurog3tm3Ggr/Neurog3tm3Ggr Tg(Vil-cre)20Syr/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60642
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a 628 bp DNA segment containing 468 bp of coding sequence, including sequences corresponding to the bHLH domain.
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurog3 Mutation:  12 strains or lines available
References
Original:  J:60642 Gradwohl G, et al., neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1607-11
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory