Mb^tm1Jsc
Targeted Allele Detail

Summary

• Symbol: Mb^tm1Jsc
• Name: myoglobin; targeted mutation 1, Jurgen Schrader
• MGI ID: MGI:2159004
• Synonyms: myo -
• Gene: Mb Location: Chr15:76899687-76934868 bp, - strand Genetic Position: Chr15, 36.36 cM
• Alliance: Mb^tm1Jsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57481
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exon 2. Northern blot analysis on RNA derived from heart of homozygous mice demonstrated that no detectable transcript is produced from this allele. No encoded protein was present in cardiac protein extracts derived from homozygous mice. (J:57481)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mb Mutation: 19 strains or lines available

References

• Original: J:57481 Godecke A, et al., Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10495-500
• All: 14 reference(s)