Oprm1^tm1Uhl
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1Uhl
• Name: opioid receptor, mu 1; targeted mutation 1, George R Uhl
• MGI ID: MGI:2159001
• Synonyms: Mor^-
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1Uhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38597
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing the first coding exon. Radioligand binding studies on whole brain minus cerebellum derived from 7 week old homozygous mice confirmed that no functional protein is expressed from this allele. (J:38597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:38597 Sora I, et al., Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1544-9
• All: 21 reference(s)