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Oprm1tm1Uhl
Targeted Allele Detail
Nomenclature
Symbol: Oprm1tm1Uhl
Name: opioid receptor, mu 1; targeted mutation 1, George R Uhl
MGI ID: MGI:2159001
Synonyms: Mor-
Gene: Oprm1  Location: Chr10:6758593-7038209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38597
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing the first coding exon. Radioligand binding studies on whole brain minus cerebellum derived from 7 week old homozygous mice confirmed that no functional protein is expressed from this allele. (J:38597)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  36 strains or lines available
References
Original:  J:38597 Sora I, et al., Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1544-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory