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Oprm1tm1Kff
Targeted Allele Detail
Nomenclature
Symbol: Oprm1tm1Kff
Name: opioid receptor, mu 1; targeted mutation 1, Brigitte L Kieffer
MGI ID: MGI:2159000
Synonyms: MOR-
Gene: Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36241
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 2. Binding assays on brain of homozygous animals confirmed that no functional protein was made from this allele. (J:36241)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  42 strains or lines available
References
Original:  J:36241 Matthes HW, et al., Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene [see comments]. Nature. 1996 Oct 31;383(6603):819-23
All:  69 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory